ABSTRACT
Purpose: To determine the long-term incidence of fellow-eye surgical involvement in patients who have undergone first-eye vitreoretinal (VR) surgery for a variety of indications. This was a single-institution retrospective, consecutive series. Methods: Eighteen years of electronic surgical data were reviewed at our institution. All patients having surgery for the following indications were included: rhegmatogenous retinal detachment (RRD), macular hole (MH), epiretinal membrane (ERM), proliferative diabetic retinopathy (PDR), vitritis, and dropped nucleus. Primary outcome was the cumulative incidence of fellow-eye surgery at 10 years by Kaplan朚eier analysis. Results: Total follow-up was 29,629 patient-years. Cumulative incidence (� standard error) of fellow-eye surgery at 10 years was 7.2% � 0.6% for RRD, 9.1% � 1.3% for ERM, 7.5% � 1.8% for MH, 30.6% � 1.9% for PDR, 13.7% � 2.9% for vitritis, and 2.8% � 1.6% for dropped nuclei. The hazard for second-eye surgery was greatest in the early postoperative period after first-eye surgery for all indications. For RRD, the hazard was 2.7% � 0.3% at year 1, 1.1% � 0.2% at year 2, and 0.5% � 0.2% at year 5. Risk factors for fellow-eye involvement for RRD were younger age (P < 0.001) and male gender (P < 0.01). Conclusion: We report the long-term risk of fellow-eye involvement in various VR pathologies, which is important in counseling patients regarding their risks as well as planning service provision.